Pharmacodynamics of a New Triazole, Posaconazole, in a Murine Model of Disseminated Candidiasis

Previous in vivo studies have characterized the pharmacodynamic characteristics of two triazole compounds, fluconazole and ravuconazole. These investigations demonstrated that the 24-h area under the concentration-time curve (AUC)/MIC ratio is the critical pharmacokinetic-pharmacodynamic (PK-PD) par...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Autores principales: Andes, D., Marchillo, K., Conklin, R., Krishna, Gopal, Ezzet, Farkad, Cacciapuoti, Anthony, Loebenberg, David
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310197/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14693531/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.1.137-142.2004
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