Pharmacodynamics of a New Triazole, Posaconazole, in a Murine Model of Disseminated Candidiasis

Previous in vivo studies have characterized the pharmacodynamic characteristics of two triazole compounds, fluconazole and ravuconazole. These investigations demonstrated that the 24-h area under the concentration-time curve (AUC)/MIC ratio is the critical pharmacokinetic-pharmacodynamic (PK-PD) par...

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Bibliographic Details
Main Authors: Andes, D., Marchillo, K., Conklin, R., Krishna, Gopal, Ezzet, Farkad, Cacciapuoti, Anthony, Loebenberg, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC310197/
https://ncbi.nlm.nih.gov/pubmed/14693531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.1.137-142.2004
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