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Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease

Recent studies show that in Alzheimer's disease (AD), alterations in neurogenesis contribute to the neurodegenerative process. Neurodegeneration in AD has been associated with aberrant signaling through the cyclin-dependent kinase-5 (CDK5) pathway via its activators p35/p25; however, the role o...

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Библиографические подробности
Главные авторы: Crews, L, Patrick, C, Adame, A, Rockenstein, E, Masliah, E
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101702/
https://ncbi.nlm.nih.gov/pubmed/21368891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.2
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