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Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease

Recent studies show that in Alzheimer's disease (AD), alterations in neurogenesis contribute to the neurodegenerative process. Neurodegeneration in AD has been associated with aberrant signaling through the cyclin-dependent kinase-5 (CDK5) pathway via its activators p35/p25; however, the role o...

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Bibliografische gegevens
Hoofdauteurs: Crews, L, Patrick, C, Adame, A, Rockenstein, E, Masliah, E
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101702/
https://ncbi.nlm.nih.gov/pubmed/21368891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.2
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