A Neuroprotective Brain-penetrating Endopeptidase Fusion Protein Ameliorates Alzheimer Disease Pathology and Restores Neurogenesis

Alzheimer disease (AD) is characterized by widespread neurodegeneration throughout the association cortex and limbic system, deposition of amyloid-β peptide (Aβ) in the neuropil and around the blood vessels, and formation of neurofibrillary tangles. The endopeptidase neprilysin has been successfully...

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Bibliographic Details
Main Authors: Spencer, Brian, Verma, Inder, Desplats, Paula, Morvinski, Dinorah, Rockenstein, Ed, Adame, Anthony, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067222/
https://ncbi.nlm.nih.gov/pubmed/24825898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557439
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