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α-Synuclein Sequesters Dnmt1 from the Nucleus: A NOVEL MECHANISM FOR EPIGENETIC ALTERATIONS IN LEWY BODY DISEASES

DNA methylation is a major epigenetic modification that regulates gene expression. Dnmt1, the maintenance DNA methylation enzyme, is abundantly expressed in the adult brain and is mainly located in the nuclear compartment, where it has access to chromatin. Hypomethylation of CpG islands at intron 1...

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書誌詳細
主要な著者: Desplats, Paula, Spencer, Brian, Coffee, Elizabeth, Patel, Pruthul, Michael, Sarah, Patrick, Christina, Adame, Anthony, Rockenstein, Edward, Masliah, Eliezer
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059002/
https://ncbi.nlm.nih.gov/pubmed/21296890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.212589
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