Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

BACKGROUND: Lewy body disease is a heterogeneous group of neurodegenerative disorders characterized by α-synuclein accumulation that includes dementia with Lewy bodies (DLB) and Parkinson's Disease (PD). Recent evidence suggests that impairment of lysosomal pathways (i.e. autophagy) involved in...

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Bibliographic Details
Main Authors: Crews, Leslie, Spencer, Brian, Desplats, Paula, Patrick, Christina, Paulino, Amy, Rockenstein, Edward, Hansen, Lawrence, Adame, Anthony, Galasko, Douglas, Masliah, Eliezer
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824828/
https://ncbi.nlm.nih.gov/pubmed/20174468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009313
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