STRUCTURAL BASIS FOR ALLOSTERIC REGULATION OF HUMAN RIBONUCLEOTIDE REDUCTASE BY NUCLEOTIDE-INDUCED OLIGOMERIZATION

Ribonucleotide reductase (RR) is an α(n)β(n) (RR1●RR2) complex that maintains balanced dNTP pools by reducing ribonucleoside diphosphates to deoxyribonucleoside diphosphates. RR1 is the catalytic subunit and RR2 houses the free radical required for catalysis. RR is allosterically regulated by its ac...

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Main Authors: Fairman, James Wesley, Wijerathna, Sanath Ranjan, Ahmad, Md. Faiz, Xu, Hai, Nakano, Ryo, Jha, Shalini, Prendergast, Jay, Welin, Martin, Flodin, Susanne, Roos, Annette, Nordlund, Pär, Li, Zongli, Walz, Thomas, Dealwis, Chris Godfrey
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101628/
https://ncbi.nlm.nih.gov/pubmed/21336276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2007
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