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Ground-State Destabilization in Orotate Phosphoribosyltransferases by Binding Isotope Effects
Orotate phosphoribosyltransferases (OPRTs) form and break the N-ribosidic bond to pyrimidines by way of ribocation-like transition states (TSs) and therefore exhibit large α-secondary [1′-(3)H] k(cat)/K(m) kinetic isotope effects (KIEs). Substrate binding isotope effects (BIEs) with OPRTs report on...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101270/ https://ncbi.nlm.nih.gov/pubmed/21526795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200638x |
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