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Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface

[Image: see text] Deletion of Phe508 from the first nucleotide-binding domain of the CFTR chloride channel causes cystic fibrosis because it inhibits protein folding. Indirect approaches such as incubation at low temperatures can partially rescue ΔF508 CFTR, but the protein is unstable at the cell s...

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Bibliographic Details
Main Authors: Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2011
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100783/
https://ncbi.nlm.nih.gov/pubmed/21520952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2004813
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