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Reduced PDZ Interactions of Rescued ΔF508CFTR Increases Its Cell Surface Mobility

Deletion of phenylalanine 508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) plasma membrane chloride channel is the most common cause of cystic fibrosis (CF). Though several maneuvers can rescue endoplasmic reticulum-retained ΔF508CFTR and promote its trafficking to the p...

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Detalhes bibliográficos
Main Authors: Valentine, Cathleen D., Lukacs, Gergely L., Verkman, Alan S., Haggie, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527949/
https://ncbi.nlm.nih.gov/pubmed/23115232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421172
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