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Reduced PDZ Interactions of Rescued ΔF508CFTR Increases Its Cell Surface Mobility
Deletion of phenylalanine 508 (ΔF508) in the cystic fibrosis transmembrane conductance regulator (CFTR) plasma membrane chloride channel is the most common cause of cystic fibrosis (CF). Though several maneuvers can rescue endoplasmic reticulum-retained ΔF508CFTR and promote its trafficking to the p...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3527949/ https://ncbi.nlm.nih.gov/pubmed/23115232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421172 |
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