Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats

After oophorectomy, mRen2.Lewis rats exhibit diastolic dysfunction associated with elevated superoxide, increased cardiac neuronal nitric oxide synthase (nNOS) expression, and diminished myocardial tetrahydrobiopterin (BH(4)) content, effects that are attenuated with selective nNOS inhibition. BH(4)...

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Bibliografiske detaljer
Main Authors: Jessup, Jewell A., Zhang, Lili, Presley, Tennille D., Kim-Shapiro, Daniel B., Wang, Hao, Chen, Alex F., Groban, Leanne
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2011
Fag:
Renal-Cardiac-Vascular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100612/
https://ncbi.nlm.nih.gov/pubmed/21427216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0061
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