Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats

After oophorectomy, mRen2.Lewis rats exhibit diastolic dysfunction associated with elevated superoxide, increased cardiac neuronal nitric oxide synthase (nNOS) expression, and diminished myocardial tetrahydrobiopterin (BH(4)) content, effects that are attenuated with selective nNOS inhibition. BH(4)...

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Detalhes bibliográficos
Main Authors: Jessup, Jewell A., Zhang, Lili, Presley, Tennille D., Kim-Shapiro, Daniel B., Wang, Hao, Chen, Alex F., Groban, Leanne
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Renal-Cardiac-Vascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100612/
https://ncbi.nlm.nih.gov/pubmed/21427216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0061
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