Attenuation of Salt-Induced Cardiac Remodeling and Diastolic Dysfunction by the GPER Agonist G-1 in Female mRen2.Lewis Rats

INTRODUCTION: The G protein-coupled estrogen receptor (GPER) is expressed in various tissues including the heart. Since the mRen2.Lewis strain exhibits salt-dependent hypertension and early diastolic dysfunction, we assessed the effects of the GPER agonist (G-1, 40 nmol/kg/hr for 14 days) or vehicle...

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Main Authors: Jessup, Jewell A., Lindsey, Sarah H., Wang, Hao, Chappell, Mark C., Groban, Leanne
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2972725/
https://ncbi.nlm.nih.gov/pubmed/21082029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015433
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