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Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats
After oophorectomy, mRen2.Lewis rats exhibit diastolic dysfunction associated with elevated superoxide, increased cardiac neuronal nitric oxide synthase (nNOS) expression, and diminished myocardial tetrahydrobiopterin (BH(4)) content, effects that are attenuated with selective nNOS inhibition. BH(4)...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Endocrine Society
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100612/ https://ncbi.nlm.nih.gov/pubmed/21427216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0061 |
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