Tetrahydrobiopterin Restores Diastolic Function and Attenuates Superoxide Production in Ovariectomized mRen2.Lewis Rats

After oophorectomy, mRen2.Lewis rats exhibit diastolic dysfunction associated with elevated superoxide, increased cardiac neuronal nitric oxide synthase (nNOS) expression, and diminished myocardial tetrahydrobiopterin (BH(4)) content, effects that are attenuated with selective nNOS inhibition. BH(4)...

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Autors principals: Jessup, Jewell A., Zhang, Lili, Presley, Tennille D., Kim-Shapiro, Daniel B., Wang, Hao, Chen, Alex F., Groban, Leanne
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2011
Matèries:
Renal-Cardiac-Vascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100612/
https://ncbi.nlm.nih.gov/pubmed/21427216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-0061
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