Human β-Globin Locus Control Region HS5 Contains CTCF- and Developmental Stage-Dependent Enhancer-Blocking Activity in Erythroid Cells

The human β-globin locus contains five developmentally regulated β-type globin genes. All five genes depend on the locus control region (LCR), located at the 5′ end of the locus, for abundant globin gene transcription. The LCR is composed of five DNase I-hypersensitive sites (HSs), at least a subset...

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Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Tanimoto, Keiji, Sugiura, Akiko, Omori, Akane, Felsenfeld, Gary, Douglas Engel, James, Fukamizu, Akiyoshi
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	Transcriptional Regulation
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645507/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.8946-8952.2003
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