Human β-Globin Locus Control Region HS5 Contains CTCF- and Developmental Stage-Dependent Enhancer-Blocking Activity in Erythroid Cells

The human β-globin locus contains five developmentally regulated β-type globin genes. All five genes depend on the locus control region (LCR), located at the 5′ end of the locus, for abundant globin gene transcription. The LCR is composed of five DNase I-hypersensitive sites (HSs), at least a subset...

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Main Authors: Tanimoto, Keiji, Sugiura, Akiko, Omori, Akane, Felsenfeld, Gary, Douglas Engel, James, Fukamizu, Akiyoshi
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2003
Ábhair:
Transcriptional Regulation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC309639/
https://ncbi.nlm.nih.gov/pubmed/14645507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.8946-8952.2003
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