Human β-Globin Locus Control Region HS5 Contains CTCF- and Developmental Stage-Dependent Enhancer-Blocking Activity in Erythroid Cells

The human β-globin locus contains five developmentally regulated β-type globin genes. All five genes depend on the locus control region (LCR), located at the 5′ end of the locus, for abundant globin gene transcription. The LCR is composed of five DNase I-hypersensitive sites (HSs), at least a subset...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Tanimoto, Keiji, Sugiura, Akiko, Omori, Akane, Felsenfeld, Gary, Douglas Engel, James, Fukamizu, Akiyoshi
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2003
Предметы:	Transcriptional Regulation
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645507/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.8946-8952.2003
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