Human β-Globin Locus Control Region HS5 Contains CTCF- and Developmental Stage-Dependent Enhancer-Blocking Activity in Erythroid Cells

The human β-globin locus contains five developmentally regulated β-type globin genes. All five genes depend on the locus control region (LCR), located at the 5′ end of the locus, for abundant globin gene transcription. The LCR is composed of five DNase I-hypersensitive sites (HSs), at least a subset...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Tanimoto, Keiji, Sugiura, Akiko, Omori, Akane, Felsenfeld, Gary, Douglas Engel, James, Fukamizu, Akiyoshi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309639/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645507/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.8946-8952.2003
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