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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

Hammerhead ribozymes are considered to be potential therapeutic agents for HIV virus because of their site-specific RNA cleavage activities. In order to elucidate structure--function relationship and also to hopefully endow ribozymes with resistance to ribonucleases, we firstly synthesized chimeric...

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Autors principals: Shimayama, T, Nishikawa, F, Nishikawa, S, Taira, K
Format: Artigo
Idioma:Inglês
Publicat: 1993
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC309588/
https://ncbi.nlm.nih.gov/pubmed/8332458
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