Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

Hammerhead ribozymes are considered to be potential therapeutic agents for HIV virus because of their site-specific RNA cleavage activities. In order to elucidate structure--function relationship and also to hopefully endow ribozymes with resistance to ribonucleases, we firstly synthesized chimeric...

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Εκδόθηκε σε:	Nucleic Acids Res
Κύριοι συγγραφείς:	Shimayama, T, Nishikawa, F, Nishikawa, S, Taira, K
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Oxford University Press 1993
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8332458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.11.2605
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