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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.
Hammerhead ribozymes are considered to be potential therapeutic agents for HIV virus because of their site-specific RNA cleavage activities. In order to elucidate structure--function relationship and also to hopefully endow ribozymes with resistance to ribonucleases, we firstly synthesized chimeric...
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| Główni autorzy: | , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
1993
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| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309588/ https://ncbi.nlm.nih.gov/pubmed/8332458 |
| Etykiety: |
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