A two-metal ion mechanism operates in the hammerhead ribozyme-mediated cleavage of an RNA substrate
Evidence for a two-metal ion mechanism for cleavage of the HH16 hammerhead ribozyme is provided by monitoring the rate of cleavage of the RNA substrate as a function of La(3+) concentration in the presence of a constant concentration of Mg(2+). We show that a bell-shaped curve of cleavage activation...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18456/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9435228/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.2.542 |
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