Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.
Hammerhead ribozymes are considered to be potential therapeutic agents for HIV virus because of their site-specific RNA cleavage activities. In order to elucidate structure--function relationship and also to hopefully endow ribozymes with resistance to ribonucleases, we firstly synthesized chimeric...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
1993
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| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8332458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.11.2605 |
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