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Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages.

Hammerhead ribozymes are considered to be potential therapeutic agents for HIV virus because of their site-specific RNA cleavage activities. In order to elucidate structure--function relationship and also to hopefully endow ribozymes with resistance to ribonucleases, we firstly synthesized chimeric...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Shimayama, T, Nishikawa, F, Nishikawa, S, Taira, K
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 1993
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309588/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8332458/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.11.2605
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