Structural basis for heterogeneous kinetics: Reengineering the hairpin ribozyme

The RNA cleavage reaction catalyzed by the hairpin ribozyme shows biphasic kinetics, and chase experiments show that the slow phase of the reaction results from reversible substrate binding to an inactive conformational isomer. To investigate the structural basis for the heterogeneous kinetics, we h...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Esteban, José A., Walter, Nils G., Kotzorek, Gerd, Heckman, Joyce E., Burke, John M.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1998
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27590/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.6091
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