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Identification of phosphate oxygens that are important for self-cleavage activity of the HDV ribozyme by phosphorothioate substitution interference analysis.

A phosphorothioate substitution interference assay was used to investigate the role of the pro-Rp oxygens of phosphate groups in the self-cleavage reaction of the genomic human hepatitis delta virus (HDV) ribozyme. Incorporation of several different phosphorothioates (NTP alpha S) into the HDV riboz...

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Detalhes bibliográficos
Main Authors: Jeoung, Y H, Kumar, P K, Suh, Y A, Taira, K, Nishikawa, S
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC308353/
https://ncbi.nlm.nih.gov/pubmed/7937083
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