New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided...

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Auteurs principaux: Sinauridze, Elena I., Romanov, Alexey N., Gribkova, Irina V., Kondakova, Olga A., Surov, Stepan S., Gorbatenko, Aleksander S., Butylin, Andrey A., Monakov, Mikhail Yu., Bogolyubov, Alexey A., Kuznetsov, Yuryi V., Sulimov, Vladimir B., Ataullakhanov, Fazoyl I.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095642/
https://ncbi.nlm.nih.gov/pubmed/21603576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019969
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