New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided...

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Hlavní autoři: Sinauridze, Elena I., Romanov, Alexey N., Gribkova, Irina V., Kondakova, Olga A., Surov, Stepan S., Gorbatenko, Aleksander S., Butylin, Andrey A., Monakov, Mikhail Yu., Bogolyubov, Alexey A., Kuznetsov, Yuryi V., Sulimov, Vladimir B., Ataullakhanov, Fazoyl I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095642/
https://ncbi.nlm.nih.gov/pubmed/21603576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019969
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