New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification

BACKGROUND: The development of new anticoagulants is an important goal for the improvement of thromboses treatments. OBJECTIVES: The design, synthesis and experimental testing of new safe and effective small molecule direct thrombin inhibitors for intravenous administration. METHODS: Computer-aided...

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Главные авторы: Sinauridze, Elena I., Romanov, Alexey N., Gribkova, Irina V., Kondakova, Olga A., Surov, Stepan S., Gorbatenko, Aleksander S., Butylin, Andrey A., Monakov, Mikhail Yu., Bogolyubov, Alexey A., Kuznetsov, Yuryi V., Sulimov, Vladimir B., Ataullakhanov, Fazoyl I.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095642/
https://ncbi.nlm.nih.gov/pubmed/21603576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019969
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