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In vivo inhibition of human CD19 targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy

Human T cells genetically modified to express chimeric antigen receptors (CARs) specific to the B cell tumor antigen CD19 can successfully eradicate systemic human CD19(+) tumors in immunocompromised SCID-Beige mice. However, in the clinical setting, CD4(+) CD25(hi) T regulatory cells (Tregs) presen...

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Detalhes bibliográficos
Main Authors: Lee, James, Hayman, Erik, Pegram, Hollie, Santos, Elmer, Heller, Glen, Sadelain, Michel, Brentjens, Renier J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094720/
https://ncbi.nlm.nih.gov/pubmed/21487038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-0552
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