Rapamycin treatment augments both protein ubiquitination and Akt activation in pressure-overloaded rat myocardium

Ubiquitin-mediated protein degradation is necessary for both increased ventricular mass and survival signaling for compensated hypertrophy in pressure-overloaded (PO) myocardium. Another molecular keystone involved in the hypertrophic growth process is the mammalian target of rapamycin (mTOR), which...

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Main Authors: Harston, Rebecca K., McKillop, John C., Moschella, Phillip C., Van Laer, An, Quinones, Lakeya S., Baicu, Catalin F., Balasubramanian, Sundaravadivel, Zile, Michael R., Kuppuswamy, Dhandapani
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2011
Assuntos:
Signaling and Stress Response
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094075/
https://ncbi.nlm.nih.gov/pubmed/21357504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00545.2010
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