In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium

Calpain activation is linked to the cleavage of several cytoskeletal proteins and could be an important contributor to the loss of cardiomyocytes and contractile dysfunction during cardiac pressure overload (PO). Using a feline right ventricular (RV) PO model, we analyzed calpain activation during t...

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Bibliografiske detaljer
Main Authors: Mani, Santhosh K., Shiraishi, Hirokazu, Balasubramanian, Sundaravadivel, Yamane, Kentaro, Chellaiah, Meenakshi, Cooper, George, Banik, Naren, Zile, Michael R., Kuppuswamy, Dhandapani
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494745/
https://ncbi.nlm.nih.gov/pubmed/18487434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00085.2008
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