In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium

Calpain activation is linked to the cleavage of several cytoskeletal proteins and could be an important contributor to the loss of cardiomyocytes and contractile dysfunction during cardiac pressure overload (PO). Using a feline right ventricular (RV) PO model, we analyzed calpain activation during t...

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Главные авторы: Mani, Santhosh K., Shiraishi, Hirokazu, Balasubramanian, Sundaravadivel, Yamane, Kentaro, Chellaiah, Meenakshi, Cooper, George, Banik, Naren, Zile, Michael R., Kuppuswamy, Dhandapani
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2008
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494745/
https://ncbi.nlm.nih.gov/pubmed/18487434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00085.2008
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