In vivo administration of calpeptin attenuates calpain activation and cardiomyocyte loss in pressure-overloaded feline myocardium

Calpain activation is linked to the cleavage of several cytoskeletal proteins and could be an important contributor to the loss of cardiomyocytes and contractile dysfunction during cardiac pressure overload (PO). Using a feline right ventricular (RV) PO model, we analyzed calpain activation during t...

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Main Authors: Mani, Santhosh K., Shiraishi, Hirokazu, Balasubramanian, Sundaravadivel, Yamane, Kentaro, Chellaiah, Meenakshi, Cooper, George, Banik, Naren, Zile, Michael R., Kuppuswamy, Dhandapani
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2008
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2494745/
https://ncbi.nlm.nih.gov/pubmed/18487434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00085.2008
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