Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design

Discriminating closely related molecules remains a major challenge in the engineering of binding proteins and inhibitors. Here we report the development of highly selective inhibitors of small ubiquitin-related modifier (SUMO) family proteins. SUMOylation is involved in the regulation of diverse cel...

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Bibliografiske detaljer
Main Authors: Gilbreth, Ryan N., Truong, Khue, Madu, Ikenna, Koide, Akiko, Wojcik, John B., Li, Nan-Sheng, Piccirilli, Joseph A., Chen, Yuan, Koide, Shohei
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093456/
https://ncbi.nlm.nih.gov/pubmed/21518904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1102294108
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