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Teaching an old scaffold new tricks: Monobodies constructed using alternative surfaces of the FN3 scaffold
The fibronectin type III domain (FN3) has become one of the most widely used non-antibody scaffolds for generating new binding proteins. Because of its structural homology to the immunoglobulin domain, combinatorial libraries of FN3 designed to date have primarily focused on introducing amino acid d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3260337/ https://ncbi.nlm.nih.gov/pubmed/22198408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.019 |
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