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Accelerating phage-display library selection by reversible and site-specific biotinylation

Immobilization of a target molecule to a solid support is an indispensable step in phage display library sorting. Here we describe an immobilization method that addresses shortcomings of existing strategies. Our method is based on the use of a polyhistidine-tagged (His-tagged) target molecule and (B...

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Bibliografische gegevens
Hoofdauteurs: Koide, Akiko, Wojcik, John, Gilbreth, Ryan N., Reichel, Annett, Piehler, Jacob, Koide, Shohei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763796/
https://ncbi.nlm.nih.gov/pubmed/19737805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp053
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