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Accelerating phage-display library selection by reversible and site-specific biotinylation

Immobilization of a target molecule to a solid support is an indispensable step in phage display library sorting. Here we describe an immobilization method that addresses shortcomings of existing strategies. Our method is based on the use of a polyhistidine-tagged (His-tagged) target molecule and (B...

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Detalhes bibliográficos
Main Authors: Koide, Akiko, Wojcik, John, Gilbreth, Ryan N., Reichel, Annett, Piehler, Jacob, Koide, Shohei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763796/
https://ncbi.nlm.nih.gov/pubmed/19737805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzp053
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