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2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

PURPOSE: The glucose analog and glycolytic inhibitor 2-deoxy-D-glucose (2-DG), which is currently under clinical evaluation for targeting cancer cells, not only blocks glycolysis thereby reducing cellular ATP, but also interferes with N-linked glycosylation, which leads to endoplasmic reticulum (ER)...

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Bibliografiske detaljer
Main Authors: Xi, Haibin, Kurtoglu, Metin, Liu, Huaping, Wangpaichitr, Medhi, You, Min, Liu, Xiongfei, Savaraj, Niramol, Lampidis, Theodore J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093301/
https://ncbi.nlm.nih.gov/pubmed/20593179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1391-0
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