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2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion
PURPOSE: The glucose analog and glycolytic inhibitor 2-deoxy-D-glucose (2-DG), which is currently under clinical evaluation for targeting cancer cells, not only blocks glycolysis thereby reducing cellular ATP, but also interferes with N-linked glycosylation, which leads to endoplasmic reticulum (ER)...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093301/ https://ncbi.nlm.nih.gov/pubmed/20593179 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1391-0 |
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