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Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress

Unregulated growth and replication as well as an abnormal microenvironment, leads to elevated levels of stress which is a common trait of cancer. By inducing both energy and endoplasmic reticulum (ER) stress, 2-Deoxy-glucose (2-DG) is particularly well-suited to take advantage of the therapeutic win...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Liu, Huaping, Kurtoglu, Metin, León-Annicchiarico, Clara Lucia, Munoz-Pinedo, Cristina, Barredo, Julio, Leclerc, Guy, Merchan, Jaime, Liu, Xiongfei, Lampidis, Theodore J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095013/
https://ncbi.nlm.nih.gov/pubmed/27183907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9263
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