Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

BCR-ABL positive (+) acute lymphoblastic leukemia (ALL) accounts for ~30% of cases of ALL. We recently demonstrated that 2-deoxy-D-glucose (2-DG), a dual energy (glycolysis inhibition) and ER-stress (N-linked-glycosylation inhibition) inducer, leads to cell death in ALL via ER-stress/UPR-mediated ap...

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Detaylı Bibliyografya
Yayımlandı:Leuk Res
Asıl Yazarlar: Leclerc, Guy J., DeSalvo, Joanna, Du, Jianfeng, Gao, Ningguo, Leclerc, Gilles M., Lehrman, Mark A., Lampidis, Theodore J., Barredo, Julio C
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783293/
https://ncbi.nlm.nih.gov/pubmed/26346348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2015.08.007
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