BCR-ABL Promotes PTEN Downregulation in Chronic Myeloid Leukemia

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as...

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Main Authors: Panuzzo, Cristina, Crivellaro, Sabrina, Carrà, Giovanna, Guerrasio, Angelo, Saglio, Giuseppe, Morotti, Alessandro
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208795/
https://ncbi.nlm.nih.gov/pubmed/25343485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110682
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