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BCR-ABL Promotes PTEN Downregulation in Chronic Myeloid Leukemia
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as...
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| Main Authors: | , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
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Public Library of Science
2014
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4208795/ https://ncbi.nlm.nih.gov/pubmed/25343485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110682 |
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