BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation

The tumor suppressive function of PTEN is exerted within 2 different cellular compartments. In the cytosol-membrane, it negatively regulates PI3K-AKT pathway through the de-phosphorylation of phosphatidylinositol (3,4,5)-triphosphate (PIP3), therefore blocking one of the major signaling transduction...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell Cycle
Autors principals: Morotti, Alessandro, Panuzzo, Cristina, Crivellaro, Sabrina, Carrà, Giovanna, Fava, Carmen, Guerrasio, Angelo, Pandolfi, Pier Paolo, Saglio, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
Matèries:
Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615112/
https://ncbi.nlm.nih.gov/pubmed/25608112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1006970
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars