BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation

The tumor suppressive function of PTEN is exerted within 2 different cellular compartments. In the cytosol-membrane, it negatively regulates PI3K-AKT pathway through the de-phosphorylation of phosphatidylinositol (3,4,5)-triphosphate (PIP3), therefore blocking one of the major signaling transduction...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Morotti, Alessandro, Panuzzo, Cristina, Crivellaro, Sabrina, Carrà, Giovanna, Fava, Carmen, Guerrasio, Angelo, Pandolfi, Pier Paolo, Saglio, Giuseppe
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615112/
https://ncbi.nlm.nih.gov/pubmed/25608112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1006970
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