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Intrinsically lower AKT, mTOR and HIF activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines

Down regulation by siRNA or absence of Hypoxic Inducible Factor (HIF-1α) has been shown to lead to increased sensitivity to glycolytic inhibitors in hypoxic tumor cells. In surveying a number of tumor types for differences in intrinsic levels of HIF under hypoxia we find that the reduction of the up...

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Autori principali: Wangpaichitr, Medhi, Savaraj, Niramol, Maher, Johnathan, Kurtoglu, Metin, Lampidis, Theodore J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587287/
https://ncbi.nlm.nih.gov/pubmed/18566221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-2334
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