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Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins
We show that cisplatin resistance in certain lung cancer cell lines can be reversed through inhibition of mTOR (mammalian Target of Rapamycin). These cell lines appear to possess high levels of phospho-mTOR, phospho-AKT and other growth-related proteins, such as hTERT (human telomerase reverse trans...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744337/ https://ncbi.nlm.nih.gov/pubmed/18585380 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2008.06.028 |
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