Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

Loss of argininosuccinate synthetase (ASS) expression in melanoma makes these tumor cells vulnerable to arginine deprivation. Pegylated arginine deiminase (ADI-PEG20) which degrades arginine to citrulline and ammonia has been used clinically and partial responses and stable disease have been noted w...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Savaraj, Niramol, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, You, Min, Bomalaski, John, He, Wei, Kuo, Macus Tien, Feun, Lynn G.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2015
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467438/
https://ncbi.nlm.nih.gov/pubmed/25749046
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