Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

Loss of argininosuccinate synthetase (ASS) expression in melanoma makes these tumor cells vulnerable to arginine deprivation. Pegylated arginine deiminase (ADI-PEG20) which degrades arginine to citrulline and ammonia has been used clinically and partial responses and stable disease have been noted w...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Savaraj, Niramol, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, You, Min, Bomalaski, John, He, Wei, Kuo, Macus Tien, Feun, Lynn G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2015
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467438/
https://ncbi.nlm.nih.gov/pubmed/25749046
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