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RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION

Recent advances in genomics have underscored the surprising ubiquity of DNA copy number variation (CNV). Fortunately, modern genotyping platforms also detect CNVs with fairly high reliability. Hidden Markov models and algorithms have played a dominant role in the interpretation of CNV data. Here we...

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Detalhes bibliográficos
Main Authors: Zhang, Zhongyang, Lange, Kenneth, Ophoff, Roel, Sabatti, Chiara
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092301/
https://ncbi.nlm.nih.gov/pubmed/21572975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/10-AOAS357
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