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Reconstructing DNA copy number by joint segmentation of multiple sequences

BACKGROUND: Variations in DNA copy number carry information on the modalities of genome evolution and mis-regulation of DNA replication in cancer cells. Their study can help localize tumor suppressor genes, distinguish different populations of cancerous cells, and identify genomic variations respons...

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Bibliographic Details
Main Authors: Zhang, Zhongyang, Lange, Kenneth, Sabatti, Chiara
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534631/
https://ncbi.nlm.nih.gov/pubmed/22897923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-205
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