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RECONSTRUCTING DNA COPY NUMBER BY PENALIZED ESTIMATION AND IMPUTATION

Recent advances in genomics have underscored the surprising ubiquity of DNA copy number variation (CNV). Fortunately, modern genotyping platforms also detect CNVs with fairly high reliability. Hidden Markov models and algorithms have played a dominant role in the interpretation of CNV data. Here we...

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Hlavní autoři: Zhang, Zhongyang, Lange, Kenneth, Ophoff, Roel, Sabatti, Chiara
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092301/
https://ncbi.nlm.nih.gov/pubmed/21572975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1214/10-AOAS357
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